{"id":1553,"date":"2025-01-03T10:18:26","date_gmt":"2025-01-03T10:18:26","guid":{"rendered":"https:\/\/terviseleht.eu\/?p=1553"},"modified":"2025-01-03T10:18:26","modified_gmt":"2025-01-03T10:18:26","slug":"psilotsubiini-saab-kasutada-raske-depressiooni-raviks","status":"publish","type":"post","link":"https:\/\/terviseleht.eu\/?p=1553","title":{"rendered":"Psilots\u00fcbiini saab kasutada raske depressiooni raviks"},"content":{"rendered":"\n

V\u00e4rskelt avaldatud uuring \u00fctleb, et nn maagilistes seentes olev \u00fchend psilots\u00fcbiin v\u00f5ib olla depressiooniravimiks ka siis, kui varem pole sobivat lahendust leitud.<\/h4>\n\n\n\n

Katses osales 12 t\u00e4iskasvanut, kellel oli raske ja seni ravile allumatu depressioon (raske raviresistentne depressioon). Pooled katsealustest olid mehed ja pooled naised ning vanust 18 kuni 65 aastat. K\u00f5iki neid oli juba ravitud v\u00e4hemalt viie erineva raviga, kuid nood polnud tulemust toonud. <\/p>\n\n\n\n

Raviks kasutasid katse l\u00e4biviinud arstid s\u00fcnteetilist psilots\u00fcbiini ja see anti patsientidele 25 mg \u00fchekordse annusena. Ps\u00fchhotroopsete ravimite kasutamine katkestati v\u00e4hemalt 2 n\u00e4dalat enne psilots\u00fcbiini andmist ja neid ei kasutatud ka v\u00e4hemalt 3 n\u00e4dalat p\u00e4rast psilots\u00fcbiiniannust.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Photo by Alexander Mass<\/em><\/p>\n\n\n\n

Ravi suure \u00fchekordse annusega<\/h3>\n\n\n\n

J\u00e4reldused, mis tehti, on lootustandvad. Esiteks on psilots\u00fcbiini andmine sellises annuses suhteliselt ohutu. Patsientide seisund paranes \u00fcsna kiiresti ning m\u00f5ju p\u00fcsis nii kolmandal n\u00e4dalal kui ka 12. n\u00e4dalal. Siiski pole ka see ravi probleemivaba – lisaks peavalule ja muudele k\u00f5rvaltoimetele, mis on taolise ravi puhul sagedased, peab olema t\u00e4helepanelik ka suitsiidim\u00f5tete ja enesevigastamise osas. <\/p>\n\n\n\n

Ka pole see ravi praeguste teadmiste juures nii t\u00f5hus siis, kui \u201ckomplektis\u201d depressiooniga k\u00e4ib ka posttraumaatiline stressih\u00e4ire.<\/p>\n\n\n\n

Teisalt on bipolaarse h\u00e4irega kaasask\u00e4iv raviresistentne depressioon suure \u00fchekordse annuse psilots\u00fcbiiniga ja kaasask\u00e4iva ps\u00fchhoteraapiaga h\u00e4sti ravitav, kuid ka siin on k\u00f5rvaltoimed sagedased.<\/p>\n\n\n\n

Kiire ja veelgi kiirem depressiooniravi<\/h3>\n\n\n\n

Kui \u201cmaagiliste seente\u201d psilots\u00fcbiin v\u00f5i selle s\u00fcnteetiline analoog on v\u00f5rreldes antidepressantidega kiire m\u00f5juga, siis ps\u00fchhodeelikumide seas on veelgi kiiremini m\u00f5juvaid aineid. Just \u00fclikiire m\u00f5ju t\u00f5ttu on tekkinud huvi l\u00fchiajalise toimega ps\u00fchhedeelikumide 5-metoks\u00fc-N,N-dimet\u00fc\u00fcltr\u00fcptamiini (5-MeO-DMT) ja N,N-dimet\u00fc\u00fcltr\u00fcptamiini (DMT) vastu. Nende m\u00f5ju on kiiruselt v\u00f5rreldav ketamiiniga ehk muidu anesteesias kasutatava ravimiga, mida kasutatakse samuti ravile allumatu raske depressiooni ja suitsiidim\u00f5tete puhul ka Eestis. <\/p>\n\n\n\n

DMT – abi 24 tunni jooksul<\/h3>\n\n\n\n

5-MeO-DMT ja DMT tehtud katses n\u00e4gid arstid depressiooni s\u00fcmptomite m\u00e4rkimisv\u00e4\u00e4rset paranemist 24 tunni jooksul ja m\u00f5ju kestis v\u00e4hemalt 1 n\u00e4dala. Positiivseks k\u00fcljeks on nende ainete puhul ka see, et tilguti all peab olema k\u00f5igest 15 kuni 30 minutit ning see ei n\u00e4i m\u00f5jutavat muu ravi t\u00f5husust.<\/p>\n\n\n\n

Uuringute viited<\/h3>\n\n\n\n

https:\/\/www.psychiatryonline.org\/doi\/10.1176\/appi.ajp.20231063<\/a><\/p>\n\n\n\n

https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2206443<\/a><\/p>\n\n\n\n

https:\/\/www.psychiatryonline.org\/doi\/10.1176\/appi.ajp.20230890<\/a><\/p>\n\n\n\n

Loe ka Skisofreenia raviks on uued ja huvitavad v\u00f5imalused<\/a><\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

V\u00e4rskelt avaldatud uuring \u00fctleb, et nn maagilistes seentes olev \u00fchend psilots\u00fcbiin v\u00f5ib olla depressiooniravimiks ka siis, kui varem pole sobivat lahendust leitud. Katses osales 12 t\u00e4iskasvanut, kellel oli raske ja… <\/p>\n","protected":false},"author":2,"featured_media":1559,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":""},"categories":[7,8],"tags":[2029,1367,2030,257,2027,2028,250,2025,469,254,2026,2024,2023],"class_list":["post-1553","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ravi-ja-ravimid","category-vaimne-tervis","tag-5-meo-dmt","tag-antidepressandid","tag-bipolaarne-haire","tag-depressioon","tag-depressiooniravi","tag-dmt","tag-ketamiin","tag-maagilised-seened","tag-posttraumaatiline-stressihaire","tag-psilotsubiin","tag-psuhhoteraapia","tag-psuhhotroopsed-ravimid","tag-raviresistentne-depressioon"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/terviseleht.eu\/index.php?rest_route=\/wp\/v2\/posts\/1553"}],"collection":[{"href":"https:\/\/terviseleht.eu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/terviseleht.eu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/terviseleht.eu\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/terviseleht.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1553"}],"version-history":[{"count":6,"href":"https:\/\/terviseleht.eu\/index.php?rest_route=\/wp\/v2\/posts\/1553\/revisions"}],"predecessor-version":[{"id":1562,"href":"https:\/\/terviseleht.eu\/index.php?rest_route=\/wp\/v2\/posts\/1553\/revisions\/1562"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/terviseleht.eu\/index.php?rest_route=\/wp\/v2\/media\/1559"}],"wp:attachment":[{"href":"https:\/\/terviseleht.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1553"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/terviseleht.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1553"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/terviseleht.eu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1553"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}